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KMID : 0860719980020000283
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Annual Bulletin of The Bum-Suk Academic Scholarship Foundation
1998 Volume.2 No. 0 p.283 ~ p.290
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A STUDY OF FACTOR XIIIa AND CD34 POSITIVE DENDRITIC CELL POPULATIONS IN NORMAL TISSUE AND CHOLESTEATOMA OTITIS MEDIA
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Abstract
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Recent advances in imunology have opened a new approach to investigating the pathogenesis and pathophysiology of cholesteatoma of the middle ear by the immunohitochemical technique. Dendritic cells include Langerhans´ cells, cutaneous indeterminate cells, paracortical interdigitating cells, and follicular dendritic cells. These cells have cytochemical and immunocytochemical characteristics of cells of the mononuclear macrophage system. The term dermal dendrocyte was first introduced by Headington in 1986 to discribe polydendritic cells in human dermis. These cells express coagulation factor XIIIa(FXIIIa) and hematopoietic progenitor antigens CD34 and thus have been regarded as originating in the bone marrow. It has been suggested that these cells may function in maintaining the immunologic competence of the host and have a central role in the pathogenesis of some focal connective tissue proliferations. The authors used an immunohitochemical method to verify the distribution of the FXIIIa and CD34 positive dendritic cells in cholesteatomatous tissues and posterior auricular skin. The distribution of the FXIIIa and CD34 positive dendritic cells in subepithelial tissues were significantly higher in cholesteatoma than in control posterior quricular skin.
These result shows that immunological processes were present in the cholesteatoma tissue and the activity of these cells might be different from that of the posterior auricular skin. It was also suggested that FXIIIa and CD34 positive dendritic cells in cholesteatoma play a certain roles in pathogenesis of cholesteatoma.
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